Private and group health plans may provide some coverage for people who meet the prescribing criteria. For more information, speak to your healthcare provider. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med ; Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. MS Society of Canada logo. Indications and use Tysabri is indicated as a monotherapy for people with relapsing-remitting MS to reduce the frequency of relapses, delay the progression of disability and reduce the number and volume of brain lesions seen on magnetic resonance imaging MRI.
Administration and dose Tysabri is administered as an intravenous into the vein injection over time an infusion in a specialized infusion centre by a health professional. Risk of PML Three factors that are known to increase the risk of PML in people treated with Tysabri: the presence of anti-JCV antibodies, longer treatment duration especially beyond 24 months and prior treatment with an immunosuppressant, which appears independent of Tysabri treatment duration.
Have questions about MS? Contact an MS Navigator: msnavigators mssociety. Search Results. Common side effects include dizziness, inflammation of the nose and throat, feeling sick, vomiting, urticaria a skin rash , shivering and an increased chance of infection. Tysabri may affect liver function but this generally recovers when treatment is stopped. It is normally kept under control by the immune system, causing no problems.
If your immune system is weakened and your body less able to fight an infection, which may occur when taking Tysabri, the JC virus can become active and cause inflammation and damage to the brain. Other factors which increase the risk of PML include previous treatment with an immunosuppressant drug for example azathioprine , cyclophosphamide , mitoxantrone or methotrexate and the length of time you have been taking Tysabri.
Your neurologist or MS nurse will discuss the implications of the blood test and how it may affect the benefits and risks of treatment. When you start taking Tysabri you will be informed of the early signs and symptoms of PML. These can be similar to an MS relapse, so it is important to report any new or worsening symptoms. If PML is suspected at any point during treatment, the drug will be discontinued immediately. Due to the potential risk of side effects, you should be given a patient alert card when you start Tysabri, containing important safety information needed before and during treatment.
A full list of side effects is included in the manufacturer's Patient Information Leaflet. Blood tests will be performed before starting treatment to determine whether you have been previously infected by the JC virus.
You should have blood and urine tests to measure blood cell counts and to check liver and kidney function. It is also important that you have had a recent usually within 3 months MRI scan. Prior to each infusion, blood pressure, temperature and pulse rate will be taken. Monitoring will also take place during the infusion and for one hour after to check for any serious allergic reaction hypersensitivity. If a previous blood test found no evidence of a JC virus infection, you should have further blood tests because it is possible to be infected at any time.
If a previous blood test found low levels of JC virus infection, you should continue to have blood tests as the virus level may increase. It is recommended that blood tests are repeated every six months. Further advice has been published for health professionals concerning monitoring for PML. During the coronavirus outbreak, you may find that your regular blood tests happen less frequently, may take place in a different location or may temporarily stop.
The Association of British Neurologists has assessed the risks and benefits of blood monitoring for people taking DMDs, and has recommended a safe minimum schedule during this period. The recommendation for Tysabri is that you should continue to have blood tests and MRI scans, if necessary, every six months. If you notice any new or worsening MS symptoms, you should contact your MS team. It depends. Tysabri and Ocrevus are effective treatment options for certain types of MS. Both drugs are used to treat the following conditions.
Consider asking your doctor whether Tysabri or Ocrevus may be a better treatment option for you. These medications have different dosing schedules and different side effects. Your doctor might recommend one drug over the other based on other medical conditions you may have or other medications you may take. See this in-depth article for more information about Tysabri.
For more information about Ocrevus, see this article. Studies have shown this medication to be effective for treating certain types of MS. This is because the drug was working to decrease relapses periods when symptoms return or worsen. Stopping Tysabri treatment may cause your symptoms to come back or worsen. At this time, there is no cure for the condition. If you feel that your symptoms are worsening or staying the same during Tysabri treatment, talk with your doctor.
They may recommend a different medication for you. Tysabri is used to treat certain types of multiple sclerosis MS in adults.
MS is a type of autoimmune disease , which means that your immune system attacks your own body. With MS, your immune system attacks the covering of your nerves, called the myelin sheath.
This can disrupt communication between your brain and spinal cord and the rest of your body. Tysabri is used to treat certain forms of MS in adults. Specifically, this medication is approved to treat:. Tysabri has been shown to be an effective treatment option in studies of people with certain types of multiple sclerosis MS. Instead, Tysabri works by preventing relapses periods when symptoms return or worsen and helping manage your symptoms.
You can also talk with your doctor or pharmacist about how well this medication may work for you. You may wonder how Tysabri is given and how often you need a dose. Note: Tysabri has other uses in addition to treating MS.
The dosage may be different for these other uses. To learn more, talk with your doctor. A healthcare professional will give you Tysabri as an infusion into your vein. Your infusion of Tysabri will likely be given over the course of 1 hour. You can receive Tysabri infusions only in certain treatment centers.
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